Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome

Biomolecules & Therapeutics

Gabsik Yang, Seon Joo Lee, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Christos C. Zouboulis, Sin-Hee Han, Kyung-Ho Ma, Jae-Ki Jang and Joo Young Lee

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Skin barrier abnormalities and immune dysfunction in atopic dermatitis

International Journal of Molecular Sciences

Gabsik Yang*, Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee 

*These authors contributed equally to this work.

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Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome

International Journal of Molecular Sciences

Gabsik Yang*, Joo Hyeon Jang*, Sung Wook Kim*, Sin-Hee Han, Kyung-Ho Ma, Jae-Ki Jang, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, and Joo Young Lee

*These authors contributed equally to this work.

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Direct binding to NLRP3 pyrin domain is a novel strategy to prevent NLRP3‐driven inflammation and gouty arthritis

Arthritis & Rheumatology

Gabsik Yang,  Hye E. Lee,  Su‐Jin Moon,  Kyung M. Ko,  Jung H. Koh,  Jin K. Seok,  Jun‐Ki Min,  Tae‐Hwe Heo,  Han C. Kang,  Yong‐Yeon Cho,  Hye S. Lee,  Katherine A. Fitzgerald, and  Joo Y. Lee

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Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis

Toxicological Research

Jea Kwon Lee, Hye Eun Lee, Gabsik Yang, Kyu-Bong Kim, Seung Jun Kwack, and Joo Young Lee

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Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells

Scientific reports​

Hye Eun Lee, Jin Young Lee, Gabsik Yang, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee and Joo Young Lee

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Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and
Mitochondrial DNA Synthesis

Molecules

Hye Eun Lee, Gabsik Yang, Youn Bum Park, Han Chang Kang , Yong-Yeon Cho, Hye Suk Lee
and Joo Young Lee

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Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber

Toxicological Research

Jae Kwon Lee*, Kyu-Bong Kim, Jung Dae Lee, Chan Young Shin, Seung Jun Kwack, Byung-Mu Lee and Joo Young Lee

*These authors contributed equally to this work.

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Immunostimulatory activity of Y-shaped DNA nanostructures mediated through the activation of TLR9

Biomedicine & Pharmacotherapy

Gabsik Yang*, Jung Eun Koo*, Hye Eun Lee, Seung Won Shin, Soong Ho Um, Joo Young Lee

*These authors contributed equally to this work.

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Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome

Phytotherapy Research

Gabsik Yang*, Hye Eun Lee*, Sang Hyeon Yeon*, Han Chang Kang, Yong‐Yeon Cho, Hye Suk Lee, Christos C. Zouboulis, Sin‐Hee Han, Jeong‐Hoon Lee, Joo Young Lee

*These authors contributed equally to this work.

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Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning

Biochemical and Biophysical Research Communications

Hye Eun Lee*, Gabsik Yang*, Sin-Hee Han, Jeong-Hoon Lee, Tae-Jin An, Jae-Ki Jang, & Joo Young Lee

*These authors contributed equally to this work.

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Efficient Transdermal Delivery of DNA Nanostructures Alleviates Atopic Dermatitis Symptoms in NC/Nga Mice

Advanced Functional Materials

Gabsik Yang*, Hye Eun Lee*, Seung Won Shin, Soong Ho Um, Jung Dae Lee, Kyu-Bong Kim, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, & Joo Young Lee

*These authors contributed equally to this work.

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Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms

Chemico biological interactions

Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee, & Joo Young Lee

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Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation

Rheumatology

Gabsik Yang*, Sang Hyeon Yeon*, Hye Eun Lee*, Han Chang Kang, Yong Yeon Cho, Hye Suk Lee, & Joo Young Lee

*These authors contributed equally to this work.

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Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice

Biomolecules & therapeutics

Hye Eun Lee, Gabsik Yang, Kyu-Bong Kim, Byung-Mu Lee, & Joo Young Lee

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Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes

Analytical and Bioanalytical Chemistry

Tae Yeon Kong, Ju-Hyun Kim, Won Gu Choi, Joo Young Lee, Hee Seung Kim, Jin Young Kim, Moon Kyo In, Hye Suk Lee

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Suppression of Primary Splenocyte Proliferation by Artemisia capillaris and Its Components

Toxicological Research

Hye Eun Lee, Gabsik Yang, Jae Sue Choi & Joo Young Lee

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Evaluation of ocular irritancy of coal-tar dyes used in cosmetics employing reconstructed human cornea-like epithelium and short time exposure tests

Food and Chemical Toxicology

Miri Lee, Ki Taek Nam, Jungah Kim, Song E Lim, Sang HyeonYeon, Bu hyun Lee, Joo Young Lee & Kyung-Min Lim

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Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.

Scientific Reports

Hye Eun Lee*, Gabsik Yang*, Nam Doo Kim, Seongkeun Jeong, Yunjin Jung, Jae Young Choi, Hyun Ho Park, & Joo Young Lee

*These authors contributed equally to this work.

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Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.

Journal of Leukocyte Biology

Sang Hyeon Yeon, Gabsik Yang, Hye Eun Lee, & Joo Young Lee

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Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production.

Journal of Investigative Dermatology

Gabsik Yang*, Jee-Woo Oh*, Hye Eun Lee, Bong Ho Lee, Kyung-Min Lim, & Joo Young Lee

*These authors contributed equally to this work.

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A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet.

Scientific Reports

Gabsik Yang*, Hye Eun Lee*, & Joo Young Lee

*These authors contributed equally to this work.

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Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/ myeloid differentiation factor2 complex in a thiol-dependent manner.

Journal of Ethnopharmacology

Jin YoungLee, ByungHoLee, NamDooKim, & JooYoungLee

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X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes.

Molecular Cancer

Jung Eun Koo, Seung Won Shin, Soong Ho Um, & Joo Young Lee.

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Gambogic Acid Disrupts Toll-like Receptor4 Activation by Blocking Lipopolysaccharides Binding to Myeloid Differentiation Factor 2.

Toxicology Research

Jin Young Lee, Byung Ho Lee, & Joo Young Lee

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A Src-family-tyrosine kinase, Lyn, is required for efficient IFN-b expression in pattern recognition receptor, RIG-I, signal pathway by interacting with IPS-1.

Cytokine

Young Ju Lim, Jung Eun Koo, Eun-Hee Hong, Zee-Yong Park , Kyung-Min Lim, Ok-Nam Bae, & Joo Young Lee.

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Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.

Immunology

Sang Hyeon Yeon, Moon Jung Song, Hye-Ri Kang, & Joo Young Lee

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PPARδ Deficiency Disrupts Hypoxia-Mediated Tumorigenic Potential of Colon Cancer Cells.

Molecular Carcinogenesis

Eunshil Jeong, Jung Eun Koo, Sang Hyeon Yeon, Mi-Kyoung Kwak, Daniel H. Hwang, & Joo Young Lee

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Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.

Biochem Biophys Res Commun.

Jung Eun Koo, Zee-Young Park, Nam Doo Kim, Joo Young Lee

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Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2.

Inflammation Research

Min Jin Kim, Na Young Choi, Jung Eun Koo, So Young Kim, Sun Myung Joung, Eunshil Jeong, & Joo Young Lee

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Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners.

Inflammation

So Young Kim, Jung Eun Koo, Mi-Ryoung Song, & Joo Young Lee

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Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2.

British Journal of Pharmacology

So Young Kim, Jung Eun Koo, Yun Jee Seo, Nisha Tyagi, Eunshil Jeong, Jaeyoung Choi, Kyung-Min Lim, Zee-Yong Park, & Joo Young Lee

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